Joint Research

Results (Published papers)

2025年度

Roux N.; Delannoy C.; Yu S.-Y.; Miura S.; Carlu L.; Besseau L.; Nakagawa T.; Sato C.; Kitajima K.; Guerardel Y.; Laudet V.

Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging

BMC Biology

https://doi.org/10.1186/s12915-025-02144-8

 

Ohno S.; Ogura C.; Yabuki A.; Itoh K.; Manabe N.; Angata K.; Togayachi A.; Aoki-Kinoshita K.; Furukawa J.-I.; Inamori K.-I.; Inokuchi J.-I.; Kaname T.; Nishihara S.; Yamaguchi Y.

VarMeter2: An enhanced structure-based method for predicting pathogenic missense variants through Mahalanobis distance

Computational and Structural Biotechnology Journal

https://doi.org/10.1016/j.csbj.2025.02.008

Yamashita K.; Ito A.; Ishida M.; Shintani Y.; Ikeda M.; Hadano S.; Izumi M.; Ochi R.

Stereoisomerism-dependent gelation and crystal structures of glycosylated N-methylbromomaleimide-based supramolecular hydrogels

Soft Matter

https://doi.org/10.1039/d4sm01325e

Fujita M.

Maintenance of the Golgi ribbon structure by the KASH protein Jaw1

Journal of Biochemistry

https://doi.org/10.1093/jb/mvae081

Kurogochi M.; Suzuki C.; Hanamatsu H.; Furukawa J.-I.

Advances in total glycomic analysis including sialylated sub-glycan isomers by SALSA method

BBA Advances

https://doi.org/10.1016/j.bbadva.2025.100144

Suzuki K.; Wu D.; Kitajima K.; Yamakawa N.; Omoto T.; Hane M.; Sato C.

Development of a permethylation-based detection method for oligo/polysialic acid structures via tandem MALDI-TOF mass spectrometry

BBA Advances

https://doi.org/10.1016/j.bbadva.2025.100155

 

Takahashi M.; Komura N.; Tanaka H.-N.; Imamura A.; Ishida H.; Ando H.

Ganglioside analog synthesis via late-stage sialylation and fatty acid introduction

Carbohydrate Research

https://doi.org/10.1016/j.carres.2025.109460

Ohkawa M.; Kamata K.; Kawsar S.M.A.; Gerdol M.; Fujii Y.; Ozeki Y.

Characterization of HOL-30: a novel tandem-repeat galectin from the marine sponge Halichondria okadai

BBA Advances

https://doi.org/10.1016/j.bbadva.2025.100153

Wang D.; Fukuda T.; Wu T.; Xu X.; Isaji T.; Gu J.

Exogenous L-fucose attenuates depression induced by chronic unpredictable stress: Implicating core fucosylation has an antidepressant potential

Journal of Biological Chemistry

https://doi.org/10.1016/j.jbc.2025.108230

Yamada K.

Minor acidic glycans: Review of focused glycomics methods

BBA Advances

https://doi.org/10.1016/j.bbadva.2025.100150

Hanamatsu H.; Suda G.; Ohara M.; Ogawa K.; Tamaki N.; Hikita H.; Haga H.; Maekawa S.; Sugiyama M.; Kakisaka T.; Nakai M.; Sho T.; Miura N.; Kurosaki M.; Asahina Y.; Taketomi A.; Ueno Y.; Takehara T.; Nishikaze T.; Furukawa J.-I.; Sakamoto N.

Elevated A2F bisect N-glycans of serum IgA reflect progression of liver fibrosis in patients with MASLD

Journal of Gastroenterology

https://doi.org/10.1007/s00535-024-02206-8

Cai Z.; Isaji T.; Liang C.; Fukuda T.; Zhang D.; Gu J.

Fucosyltransferase 4 upregulates P-gp expression for chemoresistance via NF-κB signaling pathway

Biochimica et Biophysica Acta – General Subjects

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85213213753&doi=10.1016%2fj.bbagen.2024.130753&partnerID=40&md5=61f4d96428c47d96b8c0d4d8fb814d8c

2024年度

Sun Y.; Xu X.; Wu T.; Fukuda T.; Isaji T.; Morii S.; Nakano M.; Gu J.

Core fucosylation within the Fc-FcγR degradation pathway promotes enhanced IgG levels via exogenous L-fucose

Journal of Biological Chemistry

https://doi.org/10.1016/j.jbc.2024.107558

Chythra J.N.; Guvench O.; MacKerell Jr A.D.; Yamaguchi T.; Mallajosyula S.S.

Refinement of the Drude Polarizable Force Field for Hexose Monosaccharides: Capturing Ring Conformational Dynamics with Enhanced Accuracy

Journal of Chemical Theory and Computation

https://doi.org/10.1021/acs.jctc.4c00656

 

Wu T.; Sun Y.; Wang D.; Isaji T.; Fukuda T.; Suzuki C.; Hanamatsu H.; Nishikaze T.; Tsumoto H.; Miura Y.; Furukawa J.-I.; Gu J.

The acetylglucosaminyltransferase GnT-Ⅲ regulates erythroid differentiation through ERK/MAPK signaling

Journal of Biological Chemistry

https://doi.org/10.1016/j.jbc.2024.108010

 

Hasnat M.A.; Ohmi Y.; Yesmin F.; Kambe M.; Kawamoto Y.; Bhuiyan R.H.; Mizutani M.; Hashimoto N.; Tsuchida A.; Ohkawa Y.; Kaneko K.; Tajima O.; Furukawa K.; Furukawa K.

Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells

Nagoya Journal of Medical Science

https://doi.org/10.18999/nagjms.86.3.435

Hasnat M.A.; Ohmi Y.; Yesmin F.; Kaneko K.; Kambe M.; Kitaura Y.; Ito T.; Imao Y.; Kano K.; Mishiro-Sato E.; Koyanagi H.; Kawamoto Y.; Bhuiyan R.H.; Ohkawa Y.; Tajima O.; Furukawa K.; Furukawa K.

Action Mechanisms of Exosomes Derived from GD3/GD2-Positive Glioma Cells in the Regulation of Phenotypes and Intracellular Signaling: Roles of Integrins

International Journal of Molecular Sciences

https://doi.org/10.3390/ijms252312752

Zhang Z.; Isaji T.; Oyama Y.; Liu J.; Xu Z.; Sun Y.; Fukuda T.; Lu H.; Gu J.

O-GlcNAcylation of Focal Adhesion Kinase Regulates Cell Adhesion, Migration, and Proliferation via the FAK/AKT Pathway

Biomolecules

https://doi.org/10.3390/biom14121577

Hayashi R.; Kamata K.; Gerdol M.; Fujii Y.; Hayashi T.; Onoda Y.; Kobayashi N.; Furushima S.; Ishiwata R.; Ohkawa M.; Masuda N.; Niimi Y.; Yamada M.; Adachi D.; Kawsar S.M.A.; Rajia S.; Hasan I.; Padma S.; Chatterjee B.P.; Ise Y.; Chida R.; Hasehira K.; Miyanishi N.; Kawasaki T.; Ogawa Y.; Fujita H.; Pallavicini A.; Ozeki Y.

Novel Galectins Purified from the Sponge Chondrilla australiensis: Unique Structural Features and Cytotoxic Effects on Colorectal Cancer Cells Mediated by TF-Antigen Binding

Marine Drugs

https://doi.org/10.3390/md22090400

Tang Y.-H.; Leng J.-X.; Yang G.; Gao X.-D.; Liu Y.-S.; Fujita M.

Production of CA125 with Tn antigens using a glycosylphosphatidylinositol anchoring system

Journal of Biochemistry

https://doi.org/10.1093/jb/mvae019

Hanamatsu H.; Yokota I.; Kurogochi M.; Akasaka-Manya K.; Miura N.; Manya H.; Endo T.; Nishikaze T.; Furukawa J.-I.; Tanaka K.

Direct derivatization of sialic acids and mild β-elimination for linkage-specific sialyl O-glycan analysis

Analytica Chimica Acta

https://doi.org/10.1016/j.aca.2024.342945

Fujii Y.; Kamata K.; Gerdol M.; Hasan I.; Rajia S.; Kawsar S.M.A.; Padma S.; Chatterjee B.P.; Ohkawa M.; Ishiwata R.; Yoshimoto S.; Yamada M.; Matsuzaki N.; Yamamoto K.; Niimi Y.; Miyanishi N.; Konno M.; Pallavicini A.; Kawasaki T.; Ogawa Y.; Ozeki Y.; Fujita H.

Multifunctional Cell Regulation Activities of the Mussel Lectin SeviL: Induction of Macrophage Polarization toward the M1 Functional Phenotype

Marine Drugs

https://doi.org/10.3390/md22060269

Liu J.; Isaji T.; Komatsu S.; Sun Y.; Xu X.; Fukuda T.; Fujimura T.; Takahashi S.; Gu J.

BRCC36 associates with FLT3-ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia

Cancer Science

https://doi.org/10.1111/cas.16090

Kondo Y.; Li Y.; Okajima T.

Efficient Escorting Strategy for Aggregation-Prone Notch EGF Repeats with Sparcl1

Molecules

https://doi.org/10.3390/molecules29051031

Isaji T.; Gu J.

Novel regulatory mechanisms of N-glycan sialylation: Implication of integrin and focal adhesion kinase in the regulation

Biochimica et Biophysica Acta – General Subjects

https://doi.org/10.1016/j.bbagen.2024.130617

Xu X.; Fukuda T.; Takai J.; Morii S.; Sun Y.; Liu J.; Ohno S.; Isaji T.; Yamaguchi Y.; Nakano M.; Moriguchi T.; Gu J.

Exogenous L-fucose attenuates neuroinflammation induced by lipopolysaccharide

Journal of Biological Chemistry

https://doi.org/10.1016/j.jbc.2023.105513

2023年度

Sugiura K, Kawai Y, Yamamoto A, Yoshioka H, Kiyohara Y, Iida A, Ozawa Y, Nishikawa M, Miura N, Hanamatsu H, Furukawa JI, Shinohara Y.

Exposure to brefeldin A induces unusual expression of hybrid- and complex-type free N-glycans in HepG2 cells

Biochimica et Biophysica Acta – General Subjects

https://doi.org/10.1016/j.bbagen.2023.130331

Song W, Liang C, Sun Y, Morii S, Yomogida S, Isaji T, Fukuda T, Hang Q, Hara A, Nakano M, Gu J.

Expression of GnT-III decreases chemoresistance via negatively regulating P-glycoprotein expression: Involvement of the TNFR2-NF-κB signaling pathway

J.Biol. Chem.

http://https;//doi.org/10.1016/j.jbc.2023.103051.