成果・活動記録

Record of Results and Activities

成果(発表論文)

2024年

Chythra J.N.; Guvench O.; MacKerell Jr A.D.; Yamaguchi T.; Mallajosyula S.S.

Refinement of the Drude Polarizable Force Field for Hexose Monosaccharides: Capturing Ring Conformational Dynamics with Enhanced Accuracy

Journal of Chemical Theory and Computation

https://doi.org/10.1021/acs.jctc.4c00656

 

Kong W.-Z.; Fujita M.

GlycoMaple: recent updates and applications in visualization and analysis of glycosylation pathways

Analytical and Bioanalytical Chemistry

https://doi.org/10.1007/s00216-024-05594-1

 

 

Tang Y.-H.; Leng J.-X.; Yang G.; Gao X.-D.; Liu Y.-S.; Fujita M.

Production of CA125 with Tn antigens using a glycosylphosphatidylinositol anchoring system

Journal of Biochemistry

https://doi.org/10.1093/jb/mvae019

Hanamatsu H.; Yokota I.; Kurogochi M.; Akasaka-Manya K.; Miura N.; Manya H.; Endo T.; Nishikaze T.; Furukawa J.-I.; Tanaka K.

Direct derivatization of sialic acids and mild β-elimination for linkage-specific sialyl O-glycan analysis

Analytica Chimica Acta

https://doi.org/10.1016/j.aca.2024.342945

Fujii Y.; Kamata K.; Gerdol M.; Hasan I.; Rajia S.; Kawsar S.M.A.; Padma S.; Chatterjee B.P.; Ohkawa M.; Ishiwata R.; Yoshimoto S.; Yamada M.; Matsuzaki N.; Yamamoto K.; Niimi Y.; Miyanishi N.; Konno M.; Pallavicini A.; Kawasaki T.; Ogawa Y.; Ozeki Y.; Fujita H.

Multifunctional Cell Regulation Activities of the Mussel Lectin SeviL: Induction of Macrophage Polarization toward the M1 Functional Phenotype

Marine Drugs

https://doi.org/10.3390/md22060269

Liu J.; Isaji T.; Komatsu S.; Sun Y.; Xu X.; Fukuda T.; Fujimura T.; Takahashi S.; Gu J.

BRCC36 associates with FLT3-ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia

Cancer Science

https://doi.org/10.1111/cas.16090

 

Kondo Y.; Li Y.; Okajima T.

Efficient Escorting Strategy for Aggregation-Prone Notch EGF Repeats with Sparcl1

Molecules

https://doi.org/10.3390/molecules29051031

Isaji T.; Gu J.

Novel regulatory mechanisms of N-glycan sialylation: Implication of integrin and focal adhesion kinase in the regulation

Biochimica et Biophysica Acta – General Subjects

https://doi.org/10.1016/j.bbagen.2024.130617

Xu X.; Fukuda T.; Takai J.; Morii S.; Sun Y.; Liu J.; Ohno S.; Isaji T.; Yamaguchi Y.; Nakano M.; Moriguchi T.; Gu J.

Exogenous L-fucose attenuates neuroinflammation induced by lipopolysaccharide

Journal of Biological Chemistry

https://doi.org/10.1016/j.jbc.2023.105513

Hasnat M.A.; Ohmi Y.; Yesmin F.; Kambe M.; Kawamoto Y.; Bhuiyan R.H.; Mizutani M.; Hashimoto N.; Tsuchida A.; Ohkawa Y.; Kaneko K.; Tajima O.; Furukawa K.; Furukawa K.

Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells

Nagoya Journal of Medical Science

https://doi.org/10.18999/nagjms.86.3.435

Sun Y.; Xu X.; Wu T.; Fukuda T.; Isaji T.; Morii S.; Nakano M.; Gu J.

Core fucosylation within the Fc-FcγR degradation pathway promotes enhanced IgG levels via exogenous L-fucose

Journal of Biological Chemistry

https://doi.org/10.1016/j.jbc.2024.107558

 

Hayashi R.; Kamata K.; Gerdol M.; Fujii Y.; Hayashi T.; Onoda Y.; Kobayashi N.; Furushima S.; Ishiwata R.; Ohkawa M.; Masuda N.; Niimi Y.; Yamada M.; Adachi D.; Kawsar S.M.A.; Rajia S.; Hasan I.; Padma S.; Chatterjee B.P.; Ise Y.; Chida R.; Hasehira K.; Miyanishi N.; Kawasaki T.; Ogawa Y.; Fujita H.; Pallavicini A.; Ozeki Y.

Novel Galectins Purified from the Sponge Chondrilla australiensis: Unique Structural Features and Cytotoxic Effects on Colorectal Cancer Cells Mediated by TF-Antigen Binding

Marine Drugs

https://doi.org/10.3390/md22090400

 

2023年

Gerdol M.; Nerelli D.E.; Martelossi N.; Ogawa Y.; Fujii Y.; Pallavicini A.; Ozeki Y.

Taxonomic Distribution and Molecular Evolution of Mytilectins

Marine Drugs

https://doi.org/10.3390/md21120614

Kamata K., Ohkawa M., Fujii Y., Ogawa Y., Rajia S., Yoshimoto S., Hasan I., Abe Kawsar S.M., Ishiwata R., Takakusaki S., Hayashi R., Adachi D., Hayashi T., Yamada M., Chatterjee B.P., Ozeki Y.

β-Trefoil Lectins of the Family Mytilidae from a Comparative Perspective

Trends in Carbohydrate Research

 

Hossain M.M., Rajia S., Ohkawa M., Yoshimoto S., Fujii Y., Kawsar S.M.A., Ozeki Y., Hasan I.

Physicochemical properties and antimicrobial activities of MytiLec-1, a member from the mytilectin family of mussels

International Journal of Biological Macromolecules

https://doi.org/10.1016/j.ijbiomac.2023.127628

Sun Y., Isaji T., Oyama Y., Xu X., Liu J., Hanamatsu H., Yokota I., Miura N., Furukawa J.-I., Fukuda T., Gu J.

Focal-adhesion kinase regulates the sialylation of N-glycans via the PI4KIIα-PI4P pathway

Journal of Biological Chemistry

https://doi.org/10.1016/j.jbc.2023.105051

 

Sugiura K, Kawai Y, Yamamoto A, Yoshioka H, Kiyohara Y, Iida A, Ozawa Y, Nishikawa M, Miura N, Hanamatsu H, Furukawa JI, Shinohara Y.

Exposure to brefeldin A induces unusual expression of hybrid- and complex-type free N-glycans in HepG2 cells

Biochimica et Biophysica Acta – General Subjects

https://doi.org/10.1016/j.bbagen.2023.130331

Song W, Liang C, Sun Y, Morii S, Yomogida S, Isaji T, Fukuda T, Hang Q, Hara A, Nakano M, Gu J.

Expression of GnT-III decreases chemoresistance via negatively regulating P-glycoprotein expression: Involvement of the TNFR2-NF-κB signaling pathway

J.Biol. Chem.

http://https;//doi.org/10.1016/j.jbc.2023.103051.