成果（発表論文）
2025年
Ogura, C.; Nishihara, S.
Glycosylation in Stem Cell Biology
Handbook of Experimental Pharmacology
Morozumi, M.; Ozaki, T.; Nishitsuji, K.; Takeda-Uchimura, Y.; Matsumoto, A.; Ito, S.; Imagama, S.; Ishiguro, N.; Yagi, H.; Kato, K.; Akama, T.O.; Kosugi, T.; Maruyama, S.; Kadomatsu, K.; Rosen, S.D.; Noble-Haeusslein, L.J.; Uchimura, K.
Enhanced locomotor recovery in mice lacking GlcNAc6ST1 and GlcNAc6ST4 following spinal cord injury
Life Science Alliance
Itoh, K.; Kurogochi, M.; Kaname, T.; Furukawa, J.-I.; Nishihara, S.
Neuromuscular Defects in a Drosophila Model of the Congenital Disorder of Glycosylation SLC35A2-CDG
Biomolecules
Kurogochi, M.
Tandem Mass Spectrometry Analysis of O-Glycopeptides
Trends in Glycoscience and Glycotechnology
Yoshida, H.; Matsuoka, M.
The molecular structure of the master growth regulator in plants emerges into the spotlight
Proceedings of the National Academy of Sciences of the United States of America
J N, C.; Yamaguchi, T.; Mallajosyula, S.S.
Further Refinement and Validation of the Drude Polarizable Force Field for Carboxylate and N-Acetyl amine Hexopyranose Derivatives
Journal of Chemical Theory and Computation
Tashima, Y.; Tsukamoto, Y.; Tsukamoto, N.; Kondo, Y.; Uddin, E.; Furukawa, W.; Go, S.; Arakawa, H.; Kaji, H.; Takeuchi, H.; Okajima, T.
Retention of DLK1 in the endoplasmic reticulum identifies roles for EGF-like-domain-specific O-glycans in the secretory pathway
FEBS Journal
Takahashi, M.; Yasutake, S.; Lin, S.-C.; Nishio, N.; Udagawa, T.; Tanaka, H.-N.; Imamura, A.; Ishida, H.; Wang, C.-C.; Komura, N.; Ando, H.
Investigation of the Reactivities of Halogen-Substituted Bicyclic Sialic Acid Donors and Their Application
Organic Letters
Ogawa, A.; Komura, N.; Tanaka, H.-N.; Imamura, A.; Ishida, H.; Ando, H.
Synthesis of sialylgalactose analogs via fully α-selective sialylation
Bioscience, Biotechnology and Biochemistry
Osuka, R.F.; Nagae, M.; Nakano, M.; Tanigawa, S.; Ono, K.; Tsuji, Y.; Ito, Y.; Takahashi, K.; Nishinakamura, R.; Kizuka, Y.
Selective modification of glycoprotein substrates by GnT-V in mouse kidney
iScience
Yoshida, H.; Itoh, H.; Mori, M.; Koketsu, E.; Kawamura, M.; Nishio, S.; Mori, H.; Matsuoka, M.
Photoperiodic flowering regulators are required for nitrogen-dependent flowering delay in rice under long-day condition
Nature Communications
T., Omoto, Takayuki; N., Yamakawa, Nao; D., Wu, Di; H., Mori, Hitoshi; U., Takeda, Ushio; M., Hane, Masaya; K., Kitajima, Ken; C., Sato, Chihiro
An enhanced dual detection of DMB-labeled sialic acids using high-resolution accurate mass spectrometry and fluorescence detection
BBA Advances
N., Miura, Nobuaki; T., Tabata, Tsuyoshi; Y., Ishihama, Yasushi; S., Okuda, Shujiro
Phylogenetic tree-based amino acid sequence generation for proteomics data analysis of unknown species
Computational and Structural Biotechnology Journal
K.I., Inamori, Kei Ichiro; J., Inokuchi, Jinichi
When ganglioside pathways go awry: congenital disorders and experimental insights
Journal of Human Genetics
H., Hanamatsu, Hisatoshi; G., Suda, Goki; M., Ohara, Masatsugu; M., Kurogochi, Masaki; N., Sakamoto, Naoya; J., Furukawa, Junichi
Novel glycan-related biomarker discovery by total glycomic and focused protein glycomic analyses
Journal of Human Genetics
M., Islam, Majidul; R.Y., Hasi, Rumana Yesmin; Y., Umemura, Yuta; H., Tanaka, Hidenori; Y., Kondo, Yudai; T., Ishikawa, Toshiki; M., Nagano, Minoru; H., Ali, Hanif; R., Kawakami, Ryushi; M., Aihara, Mutsumi
Method for isolation and quantification of inositol glycan produced by glycosylinositol phosphoceramide-hydrolysing phospholipase D in plants
Journal of Biochemistry
K., Kato, Koichi; S., Yanaka, Saeko; T., Yamaguchi, Takumi
The synergy of experimental and computational approaches for visualizing glycoprotein dynamics: Exploring order within the apparent disorder of glycan conformational ensembles
Current Opinion in Structural Biology
H., Yagi, Hirokazu; T., Saito, Taiki; S., Guu, Shihyun; N., Yamakawa, Nao; S., Shimamura, Shigeru; S., Kondo, Sachiko; M., Yagi-Utsumi, Maho; K., Takai, Ken; J., Furukawa, Junichi; Y., Guerardel, Yann
Uncommon N-Glycan Structures in Anhydrobiotic Tardigrades
Molecular and Cellular Proteomics
F., Xu, Fan; H., Yoshida, Hideki; C., Chu, Chengcai; M., Matsuoka, Makoto; J., Sun, Jian
Seed dormancy and germination in rice: Molecular regulatory mechanisms and breeding
Molecular Plant
Y., Nakagawa, Yu; Y., Manabe, Yuka; W., Kondo, Wataru; T., Kondo, Tatsuhiko; K., Irie, Kazuhiro
3,4-Dihydroquinolizinium Ring, the Core Structure of Quinocidin, as a Cysteine-Selective Electrophile
ChemPlusChem
C., Nagai-Okatani, Chiaki; N., Fujita, Noriaki; P., Boottanun, Patcharaporn; M., Tanaka, Miyuki; M., Shiota, Masaaki; D., Shinmachi, Daisuke; K., Angata, Kiyohiko; K.F., Aoki-Kinoshita, Kiyoko Flora; A., Kuno, Atsushi
LM-GlycoRepo Version 1.0: A Novel Repository System for Mouse Tissue Glycome Mapping Data
Journal of Proteome Research
K., Kato, Koichi; T., Watanabe, Tokio; T., Yamaguchi, Takumi
Deciphering Glycan Dynamics through Nonlinear Correlation Analysis
Chemical and Pharmaceutical Bulletin
S.L., Higashi, Sayuri L.; F., Nakagawa, Fumiko; M., Ikeda, Masato
Development of glyco-materials based on glucose derivatives through aqueous self-assembly
Chemistry Letters
H., Yagi, Hirokazu; S., Kondo, Sachiko; R., Murakami, Reiko; R., Yogo, Rina; S., Yanaka, Saeko; F., Umezawa, Fumiko; M., Yagi-Utsumi, Maho; A., Fujita, Akihiro; M., Okina, Masako; Y., Hashimoto, Yutaka
Temporal and Sex-Dependent N-Glycosylation Dynamics in Rat Serum
International Journal of Molecular Sciences
H., Kawade, Haruka; W., Bao, Wanxue; Y., Tokoro, Yuko; Y., Ito, Yoshimasa; Y., Tsuji, Yudai; K., Takahashi, Kazuo; K., Nakajima, Kazuki; M., Nakano, Miyako; Y., Kizuka, Yasuhiko
Bisecting GlcNAc modification of angiotensin-related glycoproteins in mouse kidney
Journal of Biochemistry
K., Hirano, Kazumi; H., Egawa, Hideo; S., Nishihara, Shoko
The sulfation pattern of glycosaminoglycans in human brain development and neurological disorders such as Alzheimer’s disease
American Journal of Physiology – Cell Physiology
M., Hane, Masaya; A., Naramura, Ayane; K., Hayakawa, Kaito; C., Abe, Chikara; T., Nakagawa, Takahiro; I., Kushima, Itaru; S., Furukawa, Soma; Y., Fukami, Yuki; K., Ikegami, Keisuke; K., Saigoh, Kazumasa
A highly sensitive quantitative method of polysialic acid reveals its unique changes in brain aging and neuropsychiatric disorders
Scientific Reports
Majidul Islam, Rumana Yesmin Hasi, Yuta Umemura, Hide-Nori Tanaka, Yudai Kondo, Toshiki Ishikawa, Minoru Nagano, Hanif Ali, Ryushi Kawakami, Mutsumi Aihara, and Tamotsu Tanaka
Method for isolation and quantification of inositol glycan produced by glycosylinositol phosphoceramide-hydrolyzing phospholipase D in plants
J. Biochemistry
https://doi.org/https://doi.org/10.1093/jb/mvaf013
Roux N.; Delannoy C.; Yu S.-Y.; Miura S.; Carlu L.; Besseau L.; Nakagawa T.; Sato C.; Kitajima K.; Guerardel Y.; Laudet V.
Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging
BMC Biology
Ohno S.; Ogura C.; Yabuki A.; Itoh K.; Manabe N.; Angata K.; Togayachi A.; Aoki-Kinoshita K.; Furukawa J.-I.; Inamori K.-I.; Inokuchi J.-I.; Kaname T.; Nishihara S.; Yamaguchi Y.
VarMeter2: An enhanced structure-based method for predicting pathogenic missense variants through Mahalanobis distance
Computational and Structural Biotechnology Journal
Yamashita K.; Ito A.; Ishida M.; Shintani Y.; Ikeda M.; Hadano S.; Izumi M.; Ochi R.
Stereoisomerism-dependent gelation and crystal structures of glycosylated N-methylbromomaleimide-based supramolecular hydrogels
Soft Matter
https://doi.org/10.1039/d4sm01325e
Fujita M.
Maintenance of the Golgi ribbon structure by the KASH protein Jaw1
Journal of Biochemistry
https://doi.org/10.1093/jb/mvae081
Kurogochi M.; Suzuki C.; Hanamatsu H.; Furukawa J.-I.
Advances in total glycomic analysis including sialylated sub-glycan isomers by SALSA method
BBA Advances
Suzuki K.; Wu D.; Kitajima K.; Yamakawa N.; Omoto T.; Hane M.; Sato C.
Development of a permethylation-based detection method for oligo/polysialic acid structures via tandem MALDI-TOF mass spectrometry
BBA Advances
Takahashi M.; Komura N.; Tanaka H.-N.; Imamura A.; Ishida H.; Ando H.
Ganglioside analog synthesis via late-stage sialylation and fatty acid introduction
Carbohydrate Research
https://doi.org/10.1016/j.carres.2025.109460
Ohkawa M.; Kamata K.; Kawsar S.M.A.; Gerdol M.; Fujii Y.; Ozeki Y.
Characterization of HOL-30: a novel tandem-repeat galectin from the marine sponge Halichondria okadai
BBA Advances
https://doi.org/10.1016/j.bbadva.2025.100153
Wang D.; Fukuda T.; Wu T.; Xu X.; Isaji T.; Gu J.
Exogenous L-fucose attenuates depression induced by chronic unpredictable stress: Implicating core fucosylation has an antidepressant potential
Journal of Biological Chemistry
Yamada K.
Minor acidic glycans: Review of focused glycomics methods
BBA Advances
Hanamatsu H.; Suda G.; Ohara M.; Ogawa K.; Tamaki N.; Hikita H.; Haga H.; Maekawa S.; Sugiyama M.; Kakisaka T.; Nakai M.; Sho T.; Miura N.; Kurosaki M.; Asahina Y.; Taketomi A.; Ueno Y.; Takehara T.; Nishikaze T.; Furukawa J.-I.; Sakamoto N.
Elevated A2F bisect N-glycans of serum IgA reflect progression of liver fibrosis in patients with MASLD
Journal of Gastroenterology
Cai Z.; Isaji T.; Liang C.; Fukuda T.; Zhang D.; Gu J.
Fucosyltransferase 4 upregulates P-gp expression for chemoresistance via NF-κB signaling pathway
Biochimica et Biophysica Acta – General Subjects
2024年
Yamada K.; Asada K.; Hanzawa K.; Aoki Y.; Nakajima K.; Kinoshita M.
Developing Method for Minor Acidic O-Glycan Analysis in Mucin and Cancer Cell Samples
Journal of Proteome Research
Ninagawa S.; Matsuo M.; Ying D.; Oshita S.; Aso S.; Matsushita K.; Taniguchi M.; Fueki A.; Yamashiro M.; Sugasawa K.; Saito S.; Imami K.; Kizuka Y.; Sakuma T.; Yamamoto T.; Yagi H.; Kato K.; Mori K.
UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins
eLife
Wu T.; Sun Y.; Wang D.; Isaji T.; Fukuda T.; Suzuki C.; Hanamatsu H.; Nishikaze T.; Tsumoto H.; Miura Y.; Furukawa J.-I.; Gu J.
The acetylglucosaminyltransferase GnT-Ⅲ regulates erythroid differentiation through ERK/MAPK signaling
Journal of Biological Chemistry
Hasnat M.A.; Ohmi Y.; Yesmin F.; Kaneko K.; Kambe M.; Kitaura Y.; Ito T.; Imao Y.; Kano K.; Mishiro-Sato E.; Koyanagi H.; Kawamoto Y.; Bhuiyan R.H.; Ohkawa Y.; Tajima O.; Furukawa K.; Furukawa K.
Action Mechanisms of Exosomes Derived from GD3/GD2-Positive Glioma Cells in the Regulation of Phenotypes and Intracellular Signaling: Roles of Integrins
International Journal of Molecular Sciences
Zhang Z.; Isaji T.; Oyama Y.; Liu J.; Xu Z.; Sun Y.; Fukuda T.; Lu H.; Gu J.
O-GlcNAcylation of Focal Adhesion Kinase Regulates Cell Adhesion, Migration, and Proliferation via the FAK/AKT Pathway
Biomolecules
Chythra J.N.; Guvench O.; MacKerell Jr A.D.; Yamaguchi T.; Mallajosyula S.S.
Refinement of the Drude Polarizable Force Field for Hexose Monosaccharides: Capturing Ring Conformational Dynamics with Enhanced Accuracy
Journal of Chemical Theory and Computation
https://doi.org/10.1021/acs.jctc.4c00656
Kong W.-Z.; Fujita M.
GlycoMaple: recent updates and applications in visualization and analysis of glycosylation pathways
Analytical and Bioanalytical Chemistry
https://doi.org/10.1007/s00216-024-05594-1
Tang Y.-H.; Leng J.-X.; Yang G.; Gao X.-D.; Liu Y.-S.; Fujita M.
Production of CA125 with Tn antigens using a glycosylphosphatidylinositol anchoring system
Journal of Biochemistry
Hanamatsu H.; Yokota I.; Kurogochi M.; Akasaka-Manya K.; Miura N.; Manya H.; Endo T.; Nishikaze T.; Furukawa J.-I.; Tanaka K.
Direct derivatization of sialic acids and mild β-elimination for linkage-specific sialyl O-glycan analysis
Analytica Chimica Acta
Fujii Y.; Kamata K.; Gerdol M.; Hasan I.; Rajia S.; Kawsar S.M.A.; Padma S.; Chatterjee B.P.; Ohkawa M.; Ishiwata R.; Yoshimoto S.; Yamada M.; Matsuzaki N.; Yamamoto K.; Niimi Y.; Miyanishi N.; Konno M.; Pallavicini A.; Kawasaki T.; Ogawa Y.; Ozeki Y.; Fujita H.
Multifunctional Cell Regulation Activities of the Mussel Lectin SeviL: Induction of Macrophage Polarization toward the M1 Functional Phenotype
Marine Drugs
Liu J.; Isaji T.; Komatsu S.; Sun Y.; Xu X.; Fukuda T.; Fujimura T.; Takahashi S.; Gu J.
BRCC36 associates with FLT3-ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia
Cancer Science
https://doi.org/10.1111/cas.16090
Kondo Y.; Li Y.; Okajima T.
Efficient Escorting Strategy for Aggregation-Prone Notch EGF Repeats with Sparcl1
Molecules
Isaji T.; Gu J.
Novel regulatory mechanisms of N-glycan sialylation: Implication of integrin and focal adhesion kinase in the regulation
Biochimica et Biophysica Acta – General Subjects
Xu X.; Fukuda T.; Takai J.; Morii S.; Sun Y.; Liu J.; Ohno S.; Isaji T.; Yamaguchi Y.; Nakano M.; Moriguchi T.; Gu J.
Exogenous L-fucose attenuates neuroinflammation induced by lipopolysaccharide
Journal of Biological Chemistry
Hasnat M.A.; Ohmi Y.; Yesmin F.; Kambe M.; Kawamoto Y.; Bhuiyan R.H.; Mizutani M.; Hashimoto N.; Tsuchida A.; Ohkawa Y.; Kaneko K.; Tajima O.; Furukawa K.; Furukawa K.
Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells
Nagoya Journal of Medical Science
Sun Y.; Xu X.; Wu T.; Fukuda T.; Isaji T.; Morii S.; Nakano M.; Gu J.
Core fucosylation within the Fc-FcγR degradation pathway promotes enhanced IgG levels via exogenous L-fucose
Journal of Biological Chemistry
https://doi.org/10.1016/j.jbc.2024.107558
Hayashi R.; Kamata K.; Gerdol M.; Fujii Y.; Hayashi T.; Onoda Y.; Kobayashi N.; Furushima S.; Ishiwata R.; Ohkawa M.; Masuda N.; Niimi Y.; Yamada M.; Adachi D.; Kawsar S.M.A.; Rajia S.; Hasan I.; Padma S.; Chatterjee B.P.; Ise Y.; Chida R.; Hasehira K.; Miyanishi N.; Kawasaki T.; Ogawa Y.; Fujita H.; Pallavicini A.; Ozeki Y.
Novel Galectins Purified from the Sponge Chondrilla australiensis: Unique Structural Features and Cytotoxic Effects on Colorectal Cancer Cells Mediated by TF-Antigen Binding
Marine Drugs
https://doi.org/10.3390/md22090400
2023年
Gerdol M.; Nerelli D.E.; Martelossi N.; Ogawa Y.; Fujii Y.; Pallavicini A.; Ozeki Y.
Taxonomic Distribution and Molecular Evolution of Mytilectins
Marine Drugs
Kamata K., Ohkawa M., Fujii Y., Ogawa Y., Rajia S., Yoshimoto S., Hasan I., Abe Kawsar S.M., Ishiwata R., Takakusaki S., Hayashi R., Adachi D., Hayashi T., Yamada M., Chatterjee B.P., Ozeki Y.
β-Trefoil Lectins of the Family Mytilidae from a Comparative Perspective
Trends in Carbohydrate Research
Hossain M.M., Rajia S., Ohkawa M., Yoshimoto S., Fujii Y., Kawsar S.M.A., Ozeki Y., Hasan I.
Physicochemical properties and antimicrobial activities of MytiLec-1, a member from the mytilectin family of mussels
International Journal of Biological Macromolecules
Sun Y., Isaji T., Oyama Y., Xu X., Liu J., Hanamatsu H., Yokota I., Miura N., Furukawa J.-I., Fukuda T., Gu J.
Focal-adhesion kinase regulates the sialylation of N-glycans via the PI4KIIα-PI4P pathway
Journal of Biological Chemistry
https://doi.org/10.1016/j.jbc.2023.105051
Sugiura K, Kawai Y, Yamamoto A, Yoshioka H, Kiyohara Y, Iida A, Ozawa Y, Nishikawa M, Miura N, Hanamatsu H, Furukawa JI, Shinohara Y.
Exposure to brefeldin A induces unusual expression of hybrid- and complex-type free N-glycans in HepG2 cells
Biochimica et Biophysica Acta – General Subjects
Song W, Liang C, Sun Y, Morii S, Yomogida S, Isaji T, Fukuda T, Hang Q, Hara A, Nakano M, Gu J.
Expression of GnT-III decreases chemoresistance via negatively regulating P-glycoprotein expression: Involvement of the TNFR2-NF-κB signaling pathway
J.Biol. Chem.